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Description

10.1007/s00394-015-1063-2 97

Although they had a similar age of DE onset and severity of anxiety-like K1 and K2 clusters, their clinical phenotype significantly differed

By changing the Dubosiella Muribaculum symbiotic microbiota and restoring the bile acid profile, TLR4/NF-B pathway activity is indirectly suppressed, which breaks the microbiota-inflammatory axis

NPs, when conjugated with certain ligands, provide targeted delivery to the TME and modify the TME, thereby improving therapeutic effectiveness [1517]